Equine Herpes Virus (EHV)
Although there are in fact 5 different equine herpesviruses (EHV 1-5), the one we see most commonly associated with disease in horses is EHV-1, which can cause respiratory disease, abortions and neurologic disease. Briefly, the other EHVs are:
EHV-2: Rarely causes disease.
EHV-3: This is the cause of a disease called coital exanthema, and is seen as small blisters or lesions of the external genitalia. It is spread during mating, and although there is no direct effect on fertility, some stallions will become systemically unwell. The disease typically resolves in 10-14 days.
EHV-4: A cause of low grade respiratory disease and occasional abortion.
EHV-5: An uncommon cause of primary disease but has been associated with a disease called Equine Multinodular Pulmonary Fibrosis. This causes chronically progressive and ultimately severe signs of lung failure.
Equine Herpesvirus 1
The virus ‘circulates’ in the equine population and lives quietly (a so-called latent infection) in many horses without causing disease. Most horses are probably infected early in the life, developing a mild form of respiratory disease (fever, nasal discharge) from which they recover. Especially in youngsters, this can affect a large proportion of a herd. No treatment is typically needed, although anti-inflammatories such as ‘bute’ or flunixin may be useful if the disease is resulting in dullness and loss of appetite. New infections most likely occur due to transmission from horse (such as when a new horse is introduced to a yard and is shedding the virus, even if there are no symptoms) or possibly from an activation of latent infection in the same horse – that is, the virus ‘wakes up’ and causes clinical signs.
As a normal consequence of infection with EHV-1, the infection can extend beyond the cells of the respiratory tract and enter the blood stream. It then travels throughout the body, but has two predilection sites, where it preferentially goes. One of these is the placenta where it infects blood vessels which can result in widespread disruption to the blood supply to the placenta, and ultimately abortion.
Neurologic disease (Equine Herpesmyeloencephalopathy: EHM)
The other major predilection site is the blood vessels of the spinal cord, where again the virus causes a blockage to the blood supply, essentially there are multiple spinal ‘strokes’. If sufficient damage occurs, then this results in dysfunction of the spinal cord. In mild cases there is only a mild weakness and incoordination, predominately in the hind legs, but in severe cases, the horse will be unable to stand.
Both abortions and neurologic disease can occur in outbreaks as the disease is passed from horse to horse, and thus it is essential to confirm the diagnosis and implement steps to prevent further spread.
Nasal swabs can be used to detect the virus by PCR and cultured in an attempt to grow the virus. Blood samples can be used to do the same. Two blood samples can be obtained 10-14 days apart to look for antibodies (the bodies reaction to the virus). A rise in the number between the two samples confirms the disease. In mares who abort, the placenta and foetus can be tested for the virus.
Treatment and prevention
There is no specific treatment for viral diseases. Anti-inflammatories are thought to be beneficial in EHM cases as they can limit inflammation and possibly thus the damage to the spinal cord. Anti-viral drugs are available but are not thought to be helpful in most situations as by the time signs are seen, the virus has done its damage. A vaccination is available and in the UK, it is mostly used in pregnant mares to help prevent abortion. There is also a vaccination licensed to help reduce respiratory disease, and either of these vaccinations could potentially be used to limit EHM, although none of them are licensed for this use. Ultimately, like with any vaccination programme, the more horses that are vaccinated, the less disease there will be and so there is an argument for increasing vaccination against EHV beyond the broodmare population.
The mainstay of prevention, and minimising spread of the disease in an outbreak situation is to implement excellent biosecurity practises which are aimed at stopping contact between infected or potentially infected horses, and those who have not been exposed. This could be via direct (horse- horse) contact or indirect (via people handling infected and then non-infected horses, or equipment being shared etc).
For further information regarding management of the disease, see the HBLB Codes of Practice, which are updated annually and freely available online at https://codes.hblb.org.uk/index.php/page/32
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